Based on our modern understanding,what revisions are necessary to the original one-gene / one-enzyme hypothesis?

Question

Quizplus · Accepted Answer

The original one-gene / one-enzyme hypothesis states that each gene codes for one enzyme, which has now been revised as follows: 
A) Alternative splicing can produce different polypeptides from a single gene, which can result in the production of multiple enzymes or non-enzymatic proteins from a single gene.
B) Some genes encode non-coding RNAs, which have important regulatory functions in gene expression, but do not code for enzymes.
C) While some genes do encode lipids, this is rare, and not necessarily a revision to the one-gene / one-enzyme hypothesis.
D) Some genes encode polypeptides that are not enzymes, such as structural proteins, which were not considered in the original hypothesis.
E) Some proteins may be composed of multiple polypeptides, which means that a gene may encode just one polypeptide within a larger protein, but this can still result in the production of multiple functional units.

Based on Our Modern Understanding,what Revisions Are Necessary to the Original