A mutation in a promoter region that causes the promoter sequence to more closely resemble the consensus sequence is called an up promoter mutation and decreases transcription.

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An up promoter mutation causes the promoter sequence to more closely resemble the consensus sequence and increases transcription. A mutation that causes the promoter sequence to more diverge from the consensus sequence is called a down promoter mutation and decreases transcription.

A Mutation in a Promoter Region That Causes the Promoter