A systemic infection is one which

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A systemic infection is one that affects multiple tissues or organs, rather than being confined to a single area of the body or the surface of the body. While some infections may have localized symptoms or may be initially contained by an immune response, a systemic infection has spread throughout the body and can cause more widespread symptoms. Topical antibiotics are generally not effective for treating systemic infections, which may require systemic antibiotics or other treatments.

A Systemic Infection Is One Which