The substance that changes the body temperature set-point to cause fever is

Name: The substance that changes the body temperature set-point to cause fever is
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Endogenous pyrogen is the substance that is produced by macrophages and other cells in response to infection or inflammation. It then circulates to the hypothalamus of the brain, where it changes the body temperature set-point, leading to the development of fever. None of the other choices are directly involved in producing fever.

The Substance That Changes the Body Temperature Set-Point to Cause