The most appropriate time to collect blood for culture from a person suspected of septicaemia is

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Blood culture should be collected when the person is febrile, as this is when the bacteria causing septicaemia would be at their highest levels in the bloodstream. This maximizes the chance of finding the causative organism in the blood culture, which can help guide appropriate antibiotic therapy. Collecting blood culture just after a meal or when the person is given the first dose of antibiotics can interfere with the accuracy of the results. First thing in the morning or just before a meal has no bearing on the appropriateness of blood culture collection.

The Most Appropriate Time to Collect Blood for Culture from a Person