What accounts for the most significant factor affecting how a person will respond to a given dose and drug?

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Characteristics of the drug user, including age, sex, weight, genetics, metabolism, medical conditions, and previous drug experience, can significantly affect how a person will respond to a given dose and drug. For example, a person with a slower metabolism or liver disease may be more likely to experience adverse effects or have a longer-lasting response to a drug than someone with a faster metabolism and healthy liver. Similarly, a person who has built up a tolerance to a drug or who has a history of addiction may require higher doses to achieve the same effect as someone who has never used the drug before.

What Accounts for the Most Significant Factor Affecting How a Person