Tricyclic antidepressants are believed to block the uptake of norepinephrine from the synaptic cleft.Which hypothesis is this a basis for?

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The catecholamine hypothesis of depression suggests that a deficiency in norepinephrine (a catecholamine) at certain sites in the brain is responsible for the development of depressive symptoms. Tricyclic antidepressants, which block the reuptake of norepinephrine, support this hypothesis by increasing the availability of norepinephrine in the synaptic cleft.

Tricyclic Antidepressants Are Believed to Block the Uptake of Norepinephrine