The most popular over-the-counter sleep drugs are

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Antihistamines, such as diphenhydramine (found in Benadryl) and doxylamine succinate (found in Unisom), are commonly used as over-the-counter sleep aids. They work by blocking histamine, which promotes wakefulness, and can cause drowsiness as a side effect. Benzodiazepines, such as Valium and Xanax, require a prescription and are not available over-the-counter. Antidepressants are used to treat depression and anxiety, and while some may have sedative effects, they are not primarily used as sleep aids. Taurine and ginseng are supplements that are not commonly used as sleep aids.

The Most Popular Over-The-Counter Sleep Drugs Are