Polymyxin B and daptomycin are both narrow spectrum drugs that target the cell membrane.They differ in that polymyxin B is effective against gram-negative organisms since it disrupts both the inner and outer membranes whereas daptomycin integrates only into the gram-positive cell wall creating leakage.

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Polymyxin B targets gram-negative bacteria by disrupting their outer and inner membranes, while daptomycin targets gram-positive bacteria by integrating into their cell membrane, causing leakage and cell death.

Polymyxin B and Daptomycin Are Both Narrow Spectrum Drugs That