In the presence of abundant iron in the cell, the iron binds IRP. The complex then binds to the IREs and
A) an increase in ferritin mRNA translation and a decrease in transferrin receptor mRNA stability.
B) a decrease in transferrin receptor mRNA translation and an increase in ferritin mRNA stability.
C) an increase in ferritin and transferrin receptor mRNA translation.
D) an increase in ferritin and transferrin receptor gene transcription.

Question

Quizplus · Accepted Answer

In the presence of abundant iron, iron regulatory proteins (IRPs) bind iron and dissociate from iron-responsive elements (IREs) on mRNAs. This leads to increased translation of ferritin mRNA (for iron storage) and decreased stability of transferrin receptor mRNA (for iron uptake).

In the Presence of Abundant Iron in the Cell, the Iron