Hormones synthesized by the placenta decrease the efficiency of insulin.

Question

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Hormones such as human placental lactogen, estrogen, and progesterone produced by the placenta can interfere with the action of insulin, leading to insulin resistance and glucose intolerance. This is a normal adaptation during pregnancy to ensure that enough glucose is available to support the growing fetus, but it can increase the risk of gestational diabetes in some women.

Hormones Synthesized by the Placenta Decrease the Efficiency of Insulin