Virus particles can be observed by standard transmission electron microscopy (TEM), but details of capsid structure require visualization by:
A) phase-contrast microscopy
B) scanning electron microscopy
C) cryo-electron microscopy
D) negative stain
E) bright field microscopy

Question

Quizplus · Accepted Answer

Cryo-electron microscopy is the best choice for observing details of capsid structure in virus particles. This technique uses a specialized electron microscope to flash-freeze the sample, preserving its native state and allowing for high-resolution imaging without distortion or damage. Other techniques such as negative stain or scanning electron microscopy can provide visualizations of virus particles, but may not reveal the fine details of their structure in the same way as cryo-electron microscopy.

Virus Particles Can Be Observed by Standard Transmission Electron Microscopy