Chemical synthesis of a new drug with a 15-member lactone ring structure would be predicted to be most similar to which antibiotic class and action?

Question

Quizplus · Accepted Answer

The 15-member lactone ring structure is a characteristic feature of macrolide antibiotics, which are 50S inhibitors. This is due to the ring structure allowing for specific interactions with the bacterial ribosome at the 50S subunit, interfering with protein synthesis. Gramicidin (A) is a membrane inhibitor, nalidixic acid (B) inhibits DNA synthesis, actinomycin D (C) inhibits RNA synthesis, and tetracyclines (D) inhibit the 30S subunit. None of these have the same lactone ring structure as the drug in question.

Chemical Synthesis of a New Drug with a 15-Member Lactone