Once in the cell's cytosol, FDG adds a phosphate group and proceeds with further transformation.This change in FDG results in

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The cell membrane is impermeable to both of these intermediate phosphorylated compounds, and neither can recross the cell membrane.Glucose-6-phosphate (G-6-P) continues through the next glycolytic step with its transformation into fructose-6-phosphate by the action of phosphoglucoisomerase.However, because of its chemical structure, FDG cannot be enzymatically transformed into fructose-6-phosphate (see Figure 15-1).Because FDG-6-P cannot be broken down or recross the cell membrane, it remains "trapped" within the cell.As more FDG molecules enter the cell and are transformed into FDG-6-P, they continue to accumulate within the cellular cytosol.

Once in the Cell's Cytosol, FDG Adds a Phosphate Group