A Patient Tells You That the Usual Dose of an Opioid

A patient tells you that the usual dose of an opioid drug for cancer pain no longer relieves the pain.What is your best response?

A) "We have to be careful about increasing opioid drug dosages to prevent drug addiction."
B) "You may be developing dependence on the drug and that is why it no longer relieves your pain."
C) "Your body may be adjusting to the drug,eliminating it more rapidly,and thus you will need a higher dose to achieve pain relief."
D) "The danger of increasing your opioid drug dosage is that you may experience respiratory failure."