How Is Therapy with Biological Response Modifiers (BRMs)different from Targeted

How is therapy with biological response modifiers (BRMs) different from targeted therapy?

A) There is no difference;the terms mean the same thing.
B) Targeted therapy only works on cancers that are inherited and BRMs work on all cancers.
C) BRMs are administered as oral agents whereas targeted therapies must be injected directly into the tumor to be effective.
D) BRMs affect the general immune response of anyone who takes the drug and targeted therapies only work in cancer cells that have a specific target.