A patient who has been prescribed primidone (Mysoline)also takes warfarin (Coumadin).Which laboratory blood test results indicate a possible drug interaction?

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Primidone decreases the effectiveness of anticoagulants,including warfarin.Warfarin effectiveness is measured by the INR.This value should be no less than 1.5 in a patient taking warfarin.With an INR level of only 0.5 the patient is at risk for forming clots and having a stroke,heart attack,pulmonary embolism,or deep vein thrombosis (DVT).

A Patient Who Has Been Prescribed Primidone (Mysoline)also Takes Warfarin