How does estrogen-based hormone replacement therapy (HRT)reduce perimenopausal symptoms?

Question

Quizplus · Accepted Answer

When the glandular cells of the ovary shrink,they no longer produce normal levels of estrogen.The decreased blood levels of estrogen trigger the brain to secrete GnRH,which then triggers the pituitary gland to secrete follicle stimulating hormone (FSH).Before menopause the FSH acts on the ovary and causes ovarian cells to secrete estrogen,which then inhibits the pathway through negative feedback.With nonfunctional ovarian cells unable to respond to FSH by increasing estrogen secretion,this pathway is disrupted for a time.The continued low blood levels of estrogen constantly stimulate the brain to secrete gonadotrophin releasing hormone (GnRH)in large amounts,resulting in the secretion of very large amounts of FSH.This extra FSH is useless because the ovary cannot respond to it and it has effects on other body tissues.The estrogen taken at this time suppressed GnRH and prevents excessive secretion of FSH,thereby reducing unpleasant symptoms.

How Does Estrogen-Based Hormone Replacement Therapy (HRT)reduce Perimenopausal Symptoms