As of the sixteenth century,Europeans had generally built up a greater immunity to smallpox than had the Native Americans.

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This is true. Europeans had been exposed to smallpox for centuries, while Native Americans had not been exposed to it before the arrival of Europeans. As a result, Europeans had built up immunity to the disease, while Native Americans had not. When Europeans brought smallpox to the Americas, it caused devastating epidemics among Native American populations.

As of the Sixteenth Century,Europeans Had Generally Built Up a Greater