A transition state analogue

Question

Quizplus · Accepted Answer

A transition state analogue is designed to mimic the transition state of a reaction and bind to the enzyme in a way that closely resembles the actual transition state. As a result, it binds tightly to the enzyme, often with high affinity, and can thus act as a potent inhibitor of the enzyme. It does not typically enhance the activity of the enzyme or bind via lock-and-key rather than induced-fit mechanisms. While it forms a complex with the enzyme that is energetically stable, this is because it is designed to do so and does not necessarily indicate an inherent property of transition state analogues in general.

A Transition State Analogue