Which of the following factors tend to destabilize a-helices?
A) clusters of amino acids with bulky R-groups
B) clusters of amino acids with similarly charged R-groups
C) Both of these.
D) Neither of these

Question

Quizplus · Accepted Answer

Both factors, clusters of amino acids with bulky R-groups and clusters of amino acids with similarly charged R-groups, tend to destabilize a-helices. Bulky R-groups can cause steric hindrance and disrupt the regular pattern of hydrogen bonding, while similarly charged R-groups can repel each other and interfere with the formation of stable hydrogen bonds.

Which of the Following Factors Tend to Destabilize A-Helices