The Bohr effect for oxygen binding states that A) Mb binds oxygen more tightly than Hb. B) Hb will bind oxygen very tightly when the CO₂ concentration is high. C) as the pH goes down, Hb binds oxygen less tightly. D) Hb's ability to bind oxygen increases with higher oxygen concentration.

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The Bohr effect describes how hemoglobin's oxygen binding affinity is inversely related to both acidity and the concentration of carbon dioxide. As the pH decreases (becomes more acidic), hemoglobin binds to oxygen less tightly, facilitating oxygen release to tissues that need it more, such as those metabolizing actively and producing more CO2 and H+.

The Bohr Effect for Oxygen Binding States That