In sickle-cell anemia hemoglobin
A) the four subunits of hemoglobin dissociate from one another
B) the heme group is lost from all subunits
C) the iron is in the Fe(III) form rather than the normal Fe(II)
D) groups of hemoglobin molecules aggregate with each other

Question

Quizplus · Accepted Answer

In sickle-cell anemia, the primary issue is that the hemoglobin molecules undergo abnormal aggregation due to a mutation in the beta-globin gene. This mutation causes the hemoglobin molecules to stick together, forming long, rigid structures that distort the shape of red blood cells into a sickle shape, rather than causing the subunits to dissociate, the heme group to be lost, or the iron to be in the Fe(III) form.

In Sickle-Cell Anemia Hemoglobin