How do uncoupling agents affect the electron transport chain and oxidative phosphorylation?
A) They block the flow of electrons, so protons aren't pumped, and ATP synthesis ceases.
B) They remove electrons from the chain, so less protons are pumped, and ATP synthesis decreases.
C) They block the flow of protons through the ATP synthase, so ATP synthesis ceases. Electron flow and proton pumping are also halted as a result.
D) They provide an alternative path for protons to re-enter the mitochondrial matrix, so ATP synthesis decreases. Electron flow and proton pumping are not affected.

Question

Quizplus · Accepted Answer

Uncoupling agents allow protons to bypass ATP synthase by providing an alternative pathway for them to re-enter the mitochondrial matrix. This process reduces ATP synthesis because the proton gradient is dissipated without generating ATP, but it does not affect the flow of electrons through the electron transport chain or the pumping of protons into the intermembrane space.

How Do Uncoupling Agents Affect the Electron Transport Chain and Oxidative