The phosphorylation of fructose 6-phosphate to fructose-1,6- bis phosphate is the committed step in glycolysis because
A) it is the rate-limiting step.
B) it is the most strongly exergonic step in the pathway.
C) fructose 1,6- bis phosphate can undergo no other reactions than those of glycolysis.
D) two phosphate groups are involved.

Question

Quizplus · Accepted Answer

The phosphorylation of fructose 6-phosphate to fructose-1,6-bisphosphate commits the molecule to the glycolytic pathway because, once phosphorylated, fructose-1,6-bisphosphate can no longer be used by any other pathway and must proceed through glycolysis.

The Phosphorylation of Fructose 6-Phosphate to Fructose-1,6- Bis Phosphate Is