Prions require more extensive methods of sterilization than are needed for bacterial endospores.

Question

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Prions are highly resistant to traditional methods of sterilization such as heat, radiation, and chemical treatment. In fact, prions are thought to be the most resistant of all known infectious agents, including bacterial endospores. As a result, prion-contaminated materials often require special and more extensive methods of sterilization, such as incineration or alkaline hydrolysis.

Prions Require More Extensive Methods of Sterilization Than Are Needed