Which of the Following Are True of an Off-Label Use

Which of the following are true of an off-label use of a drug? (Select all that apply. )

A) Prescribers are allowed to use drugs for off-label use under certain circumstances.
B) The FDA approves the use of drugs for specific indications,which are listed or labeled on the package insert of the drug.
C) Drug manufacturers have much useful information regarding off-label uses of their drugs on their websites.
D) Off-label use of drugs is not permitted in the United States.
E) Off-label drugs are repackaged for sale by clandestine organizations outside the United States and are illegal to transport or distribute.