The metabolite formed during metabolism (biotransformation)is usually _____ polar and _____ lipid soluble than its parent compound.

Question

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The metabolite is usually more polar and less lipid soluble than its parent compound,meaning that renal tubular reabsorption of the metabolite will be reduced because reabsorption favors lipid-soluble compounds.Metabolites are also less likely to bind to plasma or tissue proteins and less likely to be stored in fat tissue.Drugs must pass through various membranes such as cellular membranes,blood capillary membranes,and intracellular membranes.The lipid in the membranes makes them relatively impermeable to ions and polar molecules.Decreased renal tubular absorption,decreased binding to the plasma or tissue proteins,and decreased fat storage cause the metabolite to be excreted more easily.

The Metabolite Formed During Metabolism (Biotransformation)is Usually _____ Polar and _____

The Metabolite Formed During Metabolism (Biotransformation)is Usually _ Polar and _