A drug interaction between aspirin and _____ can result in significant bleeding.

Question

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The drug interaction between aspirin and warfarin can result in bleeding.Warfarin is an oral anticoagulant that is highly protein bound to plasma protein-binding sites.If aspirin is administered to a patient taking warfarin,it can displace the warfarin from its binding sites,increasing its anticoagulant effect.Aspirin interferes with probenecid's uricosuric effect and has been reported to precipitate an acute attack of gout.Aspirin can displace methotrexate from its plasma protein-binding sites and can also interfere with its clearance.This results in an increased serum concentration and methotrexate toxicity such as bone marrow depression.Higher doses of salicylates may produce a hypoglycemic effect.

A Drug Interaction Between Aspirin and _____ Can Result in Significant