Adverse cardiovascular effects are thought to be least likely to occur with the use of which of the following nonsteroidal antiinflammatory drugs (NSAIDs)?

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Naproxen (Naprosyn)and naproxen sodium OTC (Aleve)are propionic acid derivatives.They have slightly longer half-lives than ibuprofen and can be dosed on an 8- to 12-hour schedule.Aleve is dosed 220 mg every 8 to 12 hours not to exceed two tablets in the 8 to 12 hour time period.Their pharmacologic effects,adverse reactions,and efficacy are similar to those of ibuprofen.Higher doses of celecoxib (Celebrex)are associated with increased risk of adverse cardiovascular effects.Celecoxib has been associated with cholestatic jaundice,which may be related to sulfonamide allergy.The risk is highest with diclofenac (Voltaren)and lowest with naproxen (Naprosyn).

Adverse Cardiovascular Effects Are Thought to Be Least Likely to Occur