How does adding naloxone to pentazocine reduce the addiction potential of orally administered pentazocine?

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Quizplus · Accepted Answer

Naloxone is a pure opioid antagonist.It is effective parenterally but not orally because it is inactivated.If the tablet is taken by the oral route,the naloxone will not affect the analgesic potency of the pentazocine.If the contents of the tablet are injected parenterally,the naloxone will be active and will counteract the effects of the pentazocine.Naloxone is not an opioid agonist and it is inactivated when taken orally.It is not a nonsteroidal anti-inflammatory drug.

How Does Adding Naloxone to Pentazocine Reduce the Addiction Potential