Which of the following statements is true concerning clindamycin?

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Clindamycin is distributed throughout most body tissues,including bone but not to cerebrospinal fluid.Cross-resistance between clindamycin and erythromycin is often noted.An antagonistic relationship has been observed between clindamycin and erythromycin because of competition for the same binding site (50S subunit)on the bacteria.The antibacterial spectrum of clindamycin includes many gram-positive organisms and some gram-negative organisms.Similar to erythromycin,clindamycin's activity includes S.pyogenes and S.viridans,pneumococci,and S.aureus.In contrast to erythromycin,clindamycin is very active against several anaerobes,including Bacteroides fragilis and Bacteroides melaninogenicus,Fusobacterium species,Peptostreptococcus and Peptococcus species,and Actinomyces israelii.

Which of the Following Statements Is True Concerning Clindamycin