Which two agents are known to cause clinically significant drug interactions when combined with epinephrine?

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Nonselective b-blockers cause hypertension followed by reflex bradycardia when combined with epinephrine,and tricyclic antidepressants may cause an exaggerated increase in pressor response.Monoamine oxidase inhibitors and phenothiazines can interact with epinephrine,but the results are usually not clinically significant.Benzodiazepines do not significantly interact with epinephrine.

Which Two Agents Are Known to Cause Clinically Significant Drug