Which of the following general anesthetic agents was introduced in the middle 1800s and led to a dramatic reduction in surgically related mortality?

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In 1846,surgically related mortality dropped dramatically with the introduction of ether.Ether is not used today because modern operating rooms have a lot of electrical equipment and ether is highly explosive.Propofol is a recent addition to the general anesthetic armamentarium.Isoflurane was not introduced in the middle 1800s.Nitrous oxide was discovered in 1776,but it is not used as a general anesthetic.

Which of the Following General Anesthetic Agents Was Introduced in the Middle