Although a lethal dose of barbiturates can only be approximated,severe poisoning will follow the ingestion of _____ times the hypnotic dose.

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Severe poisoning will follow the ingestion of 10 times the hypnotic dose of barbiturates,and life is seriously threatened when more than 15 times the hypnotic dose is consumed.The cause of death is respiratory failure when an overdose occurs.The treatment includes conservative management and treatment of specific symptoms.Barbiturates have a narrow therapeutic index (TI),meaning the difference between an effective dose and a lethal dose is relatively small.Therefore,it is very important to know the TI for barbiturates.

Although a Lethal Dose of Barbiturates Can Only Be Approximated,severe