Chronic use of barbiturates can lead to _____ dependence.

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Physical dependence refers to the altered physiologic state that results from constantly increasing drug concentrations.The presence of physical dependence is established by withdrawal or abstinence syndrome.Psychologic dependence is a state of mind in which a person believes that he or she is unable to maintain optimal performance without having taken a drug.Chronic use of barbiturates can lead to both physical and psychologic dependence.Long-term use produces a state similar to alcohol intoxication.The barbiturate addict becomes progressively depressed and is unable to function.Tolerance develops to most effects of barbiturates but not to the lethal dose.

Chronic Use of Barbiturates Can Lead to _____ Dependence