To prevent tolerance,prophylactic nitrates should be given with at least a(n)

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Prophylactic nitrates should be given with at least an 8- to 12-hour "vacation" every day.The mononitrate dose form requires a 7-hour "vacation" daily;the first dose is given in the morning and the second dose is given 7 hours later.The "vacation" is taken in order to prevent tolerance.With long-term regular use,tolerance develops to the effects of nitrates.In fact,no difference can be detected between a long-acting nitrate and placebo when taken without a daily "vacation."

To Prevent Tolerance,prophylactic Nitrates Should Be Given with at Least