Valproate is associated with toxicity of which of the following organs?

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Valproate is associated with hepatotoxicity.Dose-related changes in liver enzymes often occur in these patients.Deaths caused by hepatic failure have also been reported.Because valproic acid can produce serious hepatotoxicity,hepatic function tests should be performed.Signs of hepatotoxicity include nausea,vomiting,abdominal pain,loss of appetite,and diarrhea.One of the other choices represents the idiosyncratic toxicity of valproate.

Valproate Is Associated with Toxicity of Which of the Following