Which agent has a narrow therapeutic index because its metabolism is a saturable process?

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At doses near the therapeutic range,phenytoin can be metabolized by a zero-order kinetic process,meaning that drug metabolism cannot keep up with the level of drug in the body.Drug levels can rise precipitously as a consequence and cause life-threatening toxicity.Phenobarbital,valproic acid,and clonazepam are metabolized in a nonsaturable (first-order kinetic)manner at doses near the therapeutic range.Gabapentin is not metabolized.

Which Agent Has a Narrow Therapeutic Index Because Its Metabolism