Leukotriene modifiers are used to manage patients with _____ that is not controlled byβ₂-agonists and corticosteroid inhibitors.

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Zafirlukast (Accolate)and montelukast (Singulair)are leukotriene receptor antagonists.They block the action of cysteinyl leukotrienes (LTRA).Zileuton (Zyflo)and zileuton,extended release (Zyflo CR)are leukotriene pathway synthesis inhibitors.They inhibit 5-lipoxygenase that catalyzes production of LT (LTD₄ and LTE₄).They are not as effective as the corticosteroid inhalers.Both are effective taken orally.Leukotriene modifiers manage asthma that is not controlled byβ₂-agonists and corticosteroid inhibitors.

Leukotriene Modifiers Are Used to Manage Patients with _____ That