Systemic absorption of a drug via the rectal route of administration is slow and often unpredictable.

Question

Quizplus · Accepted Answer

The rectal route of administration is known to have slower and often unpredictable systemic absorption of drugs. This is because the rectal wall is less permeable than other routes of administration such as the oral or sublingual routes. Additionally, the presence of fecal matter in the rectum may also affect the absorption of drugs. Therefore, rectal administration of drugs is typically reserved for cases where other routes of administration are not feasible or practical.

Systemic Absorption of a Drug Via the Rectal Route of Administration