Patients taking oral contraceptive drugs should avoid taking the herb St.John's wort for depression because it can increase the chance of getting pregnant.

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St. John's wort can interact with oral contraceptives and make them less effective, increasing the chances of unintended pregnancy. It is important for patients to discuss all herbal supplements with their healthcare provider to avoid potential interactions and adverse effects.

Patients Taking Oral Contraceptive Drugs Should Avoid Taking the Herb