What Does the Biologic Model Theory of Substance Abuse Hypothesize

What does the biologic model theory of substance abuse hypothesize? (Select all that apply.)

A) A predisposition to substance abuse based on a hereditary condition
B) Alcoholic individuals as fixated at the oral stage of development, needing satisfaction through oral behaviors such as drinking
C) Genetic aberrations that block feelings of well being, resulting in anxiety, anger, low self esteem, and other negative feelings, leaving a craving for a substance that will suppress the bad feelings
D) That genes may play a role in alteration of metabolic enzyme systems in the body that enhance or detract from pleasurable responses to chemical substances
E) That it is a person's choice of whether to use drugs, which drugs to use, how much to use, and to seek treatment for substance abuse