The temperature program for a separation starts at a temperature of 50 ^oC and ramps the temperature up to 270 ^oC at a rate of 10 ^oC/minute.Which statement is NOT true for this separation? A)At 10 ^oC/minute,a total of 22 minutes is needed to reach 270 ^oC. B)Strongly retained solutes will remain at the head of the column while the temperature is low. C)Weakly retained solutes will separate and elute early in the separation. D)The vapor pressure of strongly retained solutes will increase as temperature increases. E)Strongly retained analytes will give broad peaks.

Question

Quizplus · Accepted Answer

The statement that strongly retained analytes will give broad peaks is not necessarily true in the context of temperature-programmed separations. As the temperature increases, the vapor pressure of the analytes increases, which can lead to better elution and potentially sharper peaks for strongly retained analytes. The broadness of peaks is influenced by many factors, including the efficiency of the column and the rate of temperature increase, rather than solely by the strength of retention.

The Temperature Program for a Separation Starts at a Temperature