Which of the following is TRUE regarding lipid-anchored membrane proteins?
A)They are only present on the exoplasmic leaflet of the cell.
B)They are only present on the endoplasmic leaflet of the cell.
C)They are only present on the cytosolic leaflet of the cell.
D)They can be present on either the cytosolic or exoplasmic leaflet of the cell.

Question

Quizplus · Accepted Answer

Lipid-anchored membrane proteins can be present on either the cytosolic or exoplasmic leaflet of the cell, depending on the type of lipid anchor used. Lipid anchors such as GPI (glycosylphosphatidylinositol) are attached to the C-terminus of the protein and face the exoplasmic side, while other lipid anchors such as palmitoyl or myristoyl groups are attached to the N-terminus or internal regions of the protein, respectively, and face the cytosolic side. Therefore, lipid-anchored membrane proteins can be found in either leaflet of the cell membrane.

Which of the Following Is TRUE Regarding Lipid-Anchored Membrane Proteins