Mutations that affect the binding of an SR protein to an exonic splicing enhancer can cause exon skipping in some genes,producing mRNAs that when translated yield nonfunctional proteins.In addition to an RNA-binding domain,SR proteins also contain an RS domain that is involved in binding:

Question

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The RS domain of SR proteins is involved in protein-protein interactions, which are crucial for the assembly of the spliceosome and the regulation of alternative splicing.

Mutations That Affect the Binding of an SR Protein to an Exonic