The 45S pre-rRNA molecule

Question

Quizplus · Accepted Answer

A) The 45S pre-rRNA molecule is a key component of the nucleolus, which is responsible for ribosome biogenesis. Therefore, the molecule can organize a nucleolus when present in a single copy.
B) The 45S pre-rRNA molecule is encoded by tandemly arranged genes, which are clustered in a genomic region called the nucleolar organizer region (NOR). In human cells, this region is located on the short arms of five acrocentric chromosomes (chromosomes 13, 14, 15, 21, and 22).
C) The 45S pre-rRNA molecule contains specific methylated bases, such as 2'-O-methylated nucleotides, which are important for ribosome function. Therefore, the molecule is methylated on specific bases.

The 45S Pre-RRNA Molecule