Which of the following is true about cystic fibrosis?
A)The normal CFTR channel protein is a chloride uniporter,but CF patients have a mutation that makes it require ATP.
B)CFTR mutations result in a mutated protein,which pumps too many chloride ions out of the cell.
C)There are no treatments for patients with CF that are specifically targeted to the CFTR receptor.
D)Patients with the most common mutation make a CFTR protein that is not present in the membrane.

Question

Quizplus · Accepted Answer

Patients with the most common CFTR mutation, ΔF508, produce a mutated CFTR protein that is not properly transported to the membrane, leading to a lack of function. Choice A is incorrect because the normal CFTR channel protein is an ATP-gated chloride channel, not a uniporter. Choice B is also incorrect because CFTR mutations typically result in a decreased ability to transport chloride ions, leading to dehydration of secretions in various organs. Choice C is incorrect because there are several treatments for CF that target the CFTR receptor, such as CFTR modulators that improve the function of the mutated protein.

Which of the Following Is True About Cystic Fibrosis