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Having Misfolded Soluble or Secretory Proteins in the RER Contributes

Question 9

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Having misfolded soluble or secretory proteins in the RER contributes to what investigators call the "traffic jam," a scenario associated with a number of human diseases where the normal transport of proteins is blocked by these abnormal proteins and the inability of protein complexes to arrive at their correct site and function properly.Briefly describe how the cell overcomes this particular traffic jam by exporting the misfolded proteins out of the RER into the cytosol,where they are degraded by the proteasome.

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Essentially,the misfolded proteins have ...

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