In muscle,glycogen phosphorylase kinase can be activated by nerve stimulation even in the absence of hormonal signals.Nerve stimulation alone results in activation of glycogen phosphorylase kinase as a result of:

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Nerve stimulation leads to an influx of calcium ions into the cytosol, which elevates the cytosolic concentration of Ca²⁺. Glycogen phosphorylase kinase is activated by calcium ions, causing it to activate glycogen phosphorylase and initiate glycogen breakdown. Phosphorylation by cAMP dependent PKA, on the other hand, is not directly involved in the activation of glycogen phosphorylase kinase by nerve stimulation.

In Muscle,glycogen Phosphorylase Kinase Can Be Activated by Nerve Stimulation